Cx43 phosphorylation and cardioprotection.
نویسنده
چکیده
منابع مشابه
Sphingosine-1-phosphate signals the way for Cx43-mediated cardioprotection.
The onset of coronary occlusion caused by vasospasm, thrombosis, or atherosclerotic plaque rupture produces myocardial ischaemia, and acute myocardial infarction (AMI) can result within minutes. Reperfusion with minimal time lapse is the treatment of choice for AMI, but coronary reperfusion can also enhance myocardial injury and the induction of life-threatening cardiac arrhythmias. In 1986, it...
متن کاملNitric oxide, PKC-ε, and connexin43 are crucial for ischemic preconditioning-induced chemical gap junction uncoupling
Ischemic preconditioning (IPC) maintains connexin43 (Cx43) phosphorylation and reduces chemical gap junction (GJ) coupling in cardiomyocytes to protect against ischemic damage. However, the signal transduction pathways underlying these effects are not fully understood. Here, we investigated whether nitric oxide (NO) and protein kinase C-ε (PKC-ε) contribute to IPC-induced cardioprotection by ma...
متن کاملThe natural cardioprotective particle HDL modulates connexin43 gap junction channels.
AIMS High-density lipoprotein (HDL) is known for its cardioprotective properties independent from its cholesterol transport activity. These properties are mediated by activation of kinases such as protein kinase C (PKC). Connexin43 (Cx43) is a gap junction protein present in ventricular cardiomyocytes. PKC-dependent phosphorylation modifies Cx43 gap junction channel properties and is involved i...
متن کاملPhosphorylation of connexin-43 at serine 262 promotes a cardiac injury-resistant state.
AIMS The cardioprotective agent fibroblast growth factor 2 (FGF-2) was found previously to promote phosphorylation of connexin-43 (Cx43) at protein kinase C (PKC) sites such as serine (S) 262 at levels above those of non-stimulated hearts. We asked if other PKC-dependent cardioprotective treatments cause a similar effect, and if Cx43 phosphorylation at S262 mediates resistance to injury. METH...
متن کاملThe FGF-2-triggered protection of cardiac subsarcolemmal mitochondria from calcium overload is mitochondrial connexin 43-dependent.
AIMS Fibroblast growth factor 2 (FGF-2) protects the heart from ischaemia- and reperfusion-induced cell death by a mechanism linked to protein kinase C (PKC)ε-mediated connexin 43 (Cx43) phosphorylation. Cx43 localizes predominantly to gap junctions, but has also been detected at subsarcolemmal (SSM), but not interfibrillar (IFM), mitochondria, where it is considered important for cardioprotect...
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ورودعنوان ژورنال:
- Cardiovascular research
دوره 83 4 شماره
صفحات -
تاریخ انتشار 2009